Insurgents breached Syria’s second-largest city and clashed with government forces for the first time since 2016 on Friday, according to a war monitor and fighters.

The surprise attack sent residents fleeing and added fresh uncertainty to a region reeling from multiple wars.

The advance on Aleppo followed a shock offensive launched by insurgents Wednesday, as thousands of fighters swept through villages and towns in Syria’s north-western countryside.

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Syrian opposition fighters stand guard in Kafr Halab in the Aleppo countryside, Syria (Ghaith Alsayed/AP)

Residents fled neighbourhoods on the city’s edge because of missiles and gunfire, according to witnesses in Aleppo.

The Syrian Observatory for Human Rights, which monitors the country’s unresolved civil war, said dozens of fighters from both sides were killed.

The attack injected new violence into a region experiencing dual wars in Gaza and Lebanon involving Israel, and other conflicts, including the Syrian civil war that began in 2011.

Aleppo has not been attacked by opposition forces since they were ousted from eastern neighbourhoods in 2016 following a gruelling military campaign in which Syrian government forces were backed by Russia, Iran and its allied groups.

But this time, there was no sign of a significant pushback from government forces or their allies.

Instead, reports emerged of government forces melting away in the face of advances, and insurgents posted messages on social media calling on troops to surrender.

Robert Ford, who was the last US ambassador to Syria, said the attack showed that Syrian government forces are “extremely weak”.

In some cases, he said, they appear to have “almost been routed”.

Syrian opposition fighters stand next to a government sign after entering the village of Anjara
Syrian opposition fighters stand next to a government sign after entering the village of Anjara (Omar Albam/AP)

This week’s advances were among the largest in recent years by opposition factions, led by the Hayat Tahrir al-Sham group, or HTS, and represent the most intense fighting in north-western Syria since 2020, when government forces seized areas previously controlled by the opposition.

The offensive came as Iran-linked groups, primarily Lebanon’s Hezbollah, which has backed Syrian government forces since 2015, have been preoccupied with their own battles at home.

A ceasefire in Hezbollah’s two-month war with Israel took effect Wednesday, the day the Syrian opposition factions announced their offensive.

Israel has also escalated its attacks against Hezbollah and Iran-linked targets in Syria during the last 70 days.

The attack on Aleppo followed weeks of simmering low-level violence, including government attacks on opposition-held areas.

Turkey, which has backed Syrian opposition groups, failed in its diplomatic efforts to prevent the government attacks, which were seen as a violation of a 2019 agreement sponsored by Russia, Turkey and Iran to freeze the line of the conflict.

Turkish security officials said on Thursday that Syrian opposition groups initially launched a long-planned “limited” offensive toward Aleppo, where attacks targeting civilians originated.

However, the offensive expanded as Syrian government forces began retreating from their positions, the officials said.

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Syrian opposition fighters ride in a truck as they enter the village of Anjara, on the western outskirts of Aleppo, Syria (Omar Albam/AP)

The aim of the offensive was to re-establish the boundaries of the de-escalation zone, according to Turkish officials.

The 2016 battle for Aleppo was a turning point in the war between Syrian government forces and rebel fighters after 2011 protests against Bashar Assad’s rule turned into an all-out war.

Russia and Iran and its allied groups helped Syrian government forces reclaim control of the city that year after a gruelling military campaign and a siege that lasted for weeks.

Besides backing opposition forces, Turkey has also established a military presence in Syria, sending troops into parts of the north-west.

Separately and largely in the east of Syria, the US has supported Syrian Kurdish forces fighting Islamic State militants.

The Syrian government did not comment on insurgents breaching Aleppo city limits.

The Kremlin said on Friday that it considered the attack an encroachment on Syria’s sovereignty and that it supported the quickest possible establishment of constitutional order in the region.

“Of course, this is a violation of Syria’s sovereignty in this region,” Russian presidential spokesperson Dmitry Peskov told a press briefing.

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A destroyed Syrian army tank sits in the village of Anjara (Omar Albam/AP)

Syria’s armed forces said in a statement on Friday that they clashed with insurgents in the countryside around Aleppo and Idlib, destroying drones and heavy weaponry.

They vowed to repel the attack and accused the insurgents of spreading false information about their advances.

The Syrian Observatory for Human Rights said the insurgents detonated two car bombs on Friday at the western edge of Aleppo.

The war monitor said insurgents were also able to seize control of Saraqeb, south of Aleppo, a town at the strategic intersection of the highways linking Aleppo with Damascus and the coast.

Syrian government authorities diverted traffic from that highway on Thursday.

An insurgent commander posted a recorded message on social media calling on Aleppo residents to cooperate with the advancing forces.

Turkey’s state-run Anadolu Agency reported that the insurgents entered the city centre on Friday and now control about 70 locations in Aleppo and Idlib provinces.

Syria’s state media reported that projectiles from insurgents landed in student accommodations at Aleppo’s university in the city centre, killing four people, including two students.

Syrian armed forces said the insurgents are violating a 2019 agreement that de-escalated fighting in the area, the last remaining opposition stronghold for years.

Hezbollah was “the main force” in the government’s control of Aleppo, said Rami Abdurrahman, head of the Observatory.

In a phone call with his Syrian counterpart, Iranian Foreign Minister Abbas Araghchi described the insurgent attacks in Syria “as a plot orchestrated by the US and the Zionist regime following the regime’s defeat in Lebanon and Palestine”.

Insurgents posted videos online showing they were using drones, a new weapon for them.

It was not clear to what extent the drones were used on the battleground.

Insurgents attacked a military airbase south-east of Aleppo with drones early on Friday, destroying a helicopter, the Anadolu Agency reported.

The opposition groups also seized heavy weapons and military vehicles belonging to the government forces, the agency said.